Tightening of knots in proteins.
نویسندگان
چکیده
We perform theoretical studies of stretching of 20 proteins with knots within a coarse-grained model. The knot's ends are found to jump to well defined sequential locations that are associated with sharp turns, whereas in homopolymers they diffuse around and eventually slide off. The waiting times of the jumps are increasingly stochastic as the temperature is raised. Knots typically do not return to their native locations when a protein is released after stretching.
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ورودعنوان ژورنال:
- Physical review letters
دوره 100 5 شماره
صفحات -
تاریخ انتشار 2008